200,000 Power Needed
Buy the first three tier-5 upgrades.
Have 100 tier-4 or below upgrades distributed among the other sacrificial monkeys, excluding the first three tier 5 towers.
Have $250,000 spent on the sacrificed towers, excluding the first three tier 5 towers.
Accumulate 16,200,000 pops (or $4,050,000 cash generated) across all sacrificed towers.
If using single player, Purchase 45 Paragon Power Totems (40 if you can purchase a second Crossbow Master for Apex Plasma Master).
If using co-op, have 3 Additional Co-Op players (or 2 extra players if all have the Master Double Cross MK) with 9 additional tier-5 towers.