When you have a large enterprise application and a domain where different domains have no common elements, and it's made of large sub-models that can work independently, this still works as a single application for an end user. Therefore, the separate ways pattern is the most challenging and complex.
In such cases, a designer could create separate models that have no relationship and develop a small application on top of them. These small applications become a single application when merged together and sit on top of all sub-models.
An employer's intranet application that offers various small applications, such as those that are HR-related, issue trackers, transport, or intra-company social networks, is one such application where a designer could use the separate ways pattern.
It would be very challenging and complex to integrate applications that were developed using separate models. Therefore, you should take care before implementing this pattern.